Categories: C-C Bond Formation > Arenes, Cyclic Compounds >
Synthesis of indanes
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Recent Literature
A number of indenes have been prepared in good yields by treatment of o-bromobenzyl
zinc bromide with various terminal and internal alkynes in the presence of a
nickel catalyst. The nickel-catalyzed carboannulation reaction was successfully
extended to the synthesis of indanes using acrylates and styrene instead of an
alkyne.
R. Deng, L. Sun, Z. Li, Org. Lett., 2007,
9, 5207-5210.
An enantioselective nickel-catalyzed Negishi cross-coupling of racemic
secondary benzylic bromides and chlorides is described. The catalyst components
are commercially available and air-stable, and the reaction is not highly
oxygen- or moisture-sensitive.
F. O. Arp, G. C. Fu, J. Am. Chem. Soc., 2005, 127, 10482-10483.
A stereoselective sequence of a RhI-catalyzed conjugate addition of boronic
acids to enones followed by a Michael cyclization gives 1,2,3-trisubstituted
indans in a highly regio- and stereoselective fashion.
C. Navarro, A. G. Csák˙, Org. Lett., 2008,
10, 217-219.
