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Synthesis of 1,4-diketones

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Recent Literature

Singly occupied molecular orbital (SOMO) catalysis allows an enantioselective organocatalytic α-enolation of aldehydes. A chiral secondary amine catalyst reacts with aldehydes to form transient enamines that undergo selective one-electron oxidation to generate SOMO-activated electrophilic radical cations which are susceptible to attack by ketone-derived enol silanes.
H.-Y. Jang, J.-B. Hong, D. W. C. MacMillan, J. Am. Chem. Soc., 2007, 129, 7004-7005.