Categories: C-C Bond Formation > Cyclic compounds > Cyclic enones

Synthesis of cyclobutenones

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Recent Literature

A tandem Michael addition/cyclic 1,2-addition/elimination of 2,3-allenoates and organozinc reagents enables the synthesis of polysubstituted cyclobutenones, which are not readily available from traditional methods due to the intrinsic ring strain. Application to the synthesis of stereodefined β,γ-unsaturated enones is demonstrated.
G. Chai, S. Wu, C. Fu, S. Ma, J. Am. Chem. Soc., 2011, 133, 3740-3743.