Categories: C-C Bond Formation > Cyclic compounds > Cyclic enones
Synthesis of cycloheptenones and higher homologues
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Recent Literature
[ReBr(CO)3(thf)]2 catalyzes the reaction of a
1,3-dicarbonyl cyclic compound with an acetylene to give a medium-sized cyclic
compound in excellent yield. By using isocyanide as an additive, the insertion
of acetylenes into a carbon-carbon single bond occurs under mild conditions.
Y. Kuninobu, A. Kawata, K. Takai, J. Am. Chem. Soc., 2006, 128,
11368-11369.
An efficient and regioselective Yb(OTf)3-promoted palladium-catalyzed
oxidative cyclization of γ-heteroalkenyl β-keto amides has been developed. Under
simple aerobic condition, various six-, seven-, and eight-membered-ring N-
and O-heterocycles were obtained in excellent yield.
K.-T. Yip, J.-H. Li, O.-Y. Lee, D. Yang, Org. Lett., 2005, 7,
5717-5719.
