Categories: C-C Bond Formation > Oxygen-containing molecules >

Synthesis of 1,2-diols

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Name Reactions

Pinacol Coupling Reaction

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Recent Literature

A tandem Wittig Rearrangement/aldol reaction of O-benzyl or O-allyl glycolate esters generates two carbon-carbon bonds and two contiguous stereocenters with excellent diastereoselectivity in a single step from simple starting materials. The [1,2]-Wittig rearrangement proceeds under very mild reaction conditions.
M. B. Betrand, J. P. Wolfe, Org. Lett., 2006, 8, 4661-4663.

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