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Synthesis of fluoroalkanes, perfluoralkanes and related compounds

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Synthesis of          

Trifluoromethylcarbinols
           


Recent Literature


In the presence of molecular sieves in DMSO, trifluoromethylation of various aldehydes and ketones with trifluoromethyltrimethylsilane proceeded very smoothly to give the corresponding trifluoromethylated adduct in good to quantitative yields without a base catalyst.
K. Iwanami, T. Oriyama, Synlett, 2006, 112-114.


A nucleophilic trifluoromethylation reaction of carbonyl compounds with Ruppert’s reagent, Me3SiCF3, was efficiently promoted by a P(t-Bu)3-DMF system. Imines were also converted to the desired α-trifluoromethyl amines under similar reaction conditions.
S. Mizuta, N. Shibata, T. Sato, H. Fujimoto, S. Nakamura, T. Toru, Synlett, 2006, 267-270.


S. Mizuta, N. Shibata, T. Sato, H. Fujimoto, S. Nakamura, T. Toru, Synlett, 2006, 267-270.