Categories: C-C Bond Formation > Heteroatom-containing Molecules > (Poly)Chlorinated Alkanes, Trihalomethylcarbinols

Synthesis of trichloromethylcarbinols

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Trihaloacetic acids can been converted to trichloromethyl and tribromomethyl ketones in good yield by a catalyzed reaction with aldehydes followed by oxidation. A coupling of organozinc intermediates with trichloroacetyl chloride gives trichloromethyl ketones.
E. J. Corey, J. O. Link, Y. Shao, Tetrahedron Lett., 1992, 33, 3435-3438.