Categories: C-C Bond Formation > Oxygen-containing molecules >

Homologations and chain extensions

Name Reactions

Arndt-Eistert Synthesis

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Recent Literature

The reaction of β-keto esters with CF₃CO₂ZnCH₂I provided the corresponding chain-extended products in moderate to good yields. α-Substituted acyclic β-keto esters reacted less efficiently than cyclic β-keto esters or simple β-keto esters.
S. Xue, Y.-K. Liu, L.-Z. Li, Q.-X. Guo, J. Org. Chem., 2005, 70, 8245-8247.

S. Xue, Y.-K. Liu, L.-Z. Li, Q.-X. Guo, J. Org. Chem., 2005, 70, 8245-8247.