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Synthesis of β-Amino Acids and Derivatives

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An efficient asymmetric 1,4-addition of arylboronic acids to β-phthaliminoacrylate esters was realized by use of a hydroxorhodium/chiral diene complex to give high yields of β-aryl-β-amino acid esters with excellent enantioselectivity.
T. Nishimura, J. Wang, M. Nagaosa, K. Okamoto, R. Shintani, F.-y. Kwong, W.-y. Yu, A. S. C. Chan, T. Hayashi, J. Am. Chem. Soc., 2010, 132, 464-465.

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A catalytic, asymmetric conjugate addition of carbamates to enoyl systems provides a highly enantioselective two-step access to N-protected β-amino acids.
C. Palomo, M. Oiarbide, R. Halder, M. Kelso, E. Gómez-Bengoa, J. García, J. Am. Chem. Soc., 2004, 126, 9188-9189.