Categories: C-C Bond Formation > Nitrogen-containing molecules > Nitriles
Synthesis of Vinyl Nitriles
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Recent Literature
Lewis-acid catalysts such as AlMe3, AlMe2Cl, and BPh3 significantly improve
the efficiency of the nickel-catalyzed aryl- and alkenylcyanation of alkynes.
Electron-rich cyanides, which exhibit poor reactivity in the absence of Lewis
acids, readily undergo the arylcyanation reaction under the newly disclosed
conditions.
Y. Nakao, A. Yada, S. Ebata, T. Hiyama, J. Am. Chem. Soc., 2007,
129, 2428-2429.
Y. Nakao, A. Yada, S. Ebata, T. Hiyama, J. Am. Chem. Soc., 2007,
129, 2428-2429.
Y. Nakao, A. Yada, S. Ebata, T. Hiyama, J. Am. Chem. Soc., 2007,
129, 2428-2429.
Related
A simple three-step single-pot procedure for Z-stereoselective synthesis
of β-monosubstituted acrylonitriles involves olefination of aldehydes with an in
situ generated α-diaminoboryl carbanion species. Various aromatic and aliphatic
aldehydes were smoothly converted into the corresponding (Z)-olefin
products in good yields.
T. Tomioka, Y. Takahashi, T. G. Vaughan, T. Yanase, Org. Lett., 2010,
12, 2171-2173.
