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Synthesis of Sulfonamides

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A palladium-catalyzed three-component synthesis of arylmethylsulfonamide derivatives from sulfonamides, paraformaldehyde, and arylboronic acids is operationally simple and provides a broad range of structurally interesting sulfonamidomethyl compounds.
T. Beisel, G. Manolikakes, Synthesis, 2016, 48, 379-386.


Ni-catalyzed stereoconvergent Negishi arylations and alkenylations of racemic α-bromosulfonamides and -sulfones furnish cross-coupling product in very good ee and yield for an array of reaction partners. Mechanistic studies are consistent with the generation of a radical intermediate.
J. Choi, P. Martín-Gago, G. C. Fu, J. Am. Chem. Soc., 2014, 136, 12161-12165.