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Categories: C-Cl Bond Formation, C-N Bond Formation > Amines

Synthesis of 1,2-chloroamines

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A practical, regio- and diastereoselective synthesis of vicinal chloramines from electron-deficient olefins and Chloramine-T is promoted by Brønsted acids in water. This novel protocol is efficient, mild, ecofriendly, and broadly applicable for the aminochlorination of various electron-deficient olefins including α,β-unsaturated ketones, cinnamate, and cinnamide.
X.-L. Wu, G.-W. Wang, J. Org. Chem., 2007, 72, 9398-9401.


Regio- and Stereoselective Copper-Catalyzed Synthesis of Vicinal Haloamino Ketones from α,β-Unsaturated Ketones
D. Chen, C. Timmons, S. Chao, G. Li, Eur. J. Org. Chem., 2004, 3097-3101.


Regio- and Stereoselective Copper-Catalyzed Synthesis of Vicinal Haloamino Ketones from α,β-Unsaturated Ketones
D. Chen, C. Timmons, S. Chao, G. Li, Eur. J. Org. Chem., 2004, 3097-3101.