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C-H Bond Formation

Reactions


Decarboxylations, Decarbonylations


Dehalogenations and other Reductive Cleavages


Decyanations


Deoxygenations


Protodeboronations


Desilylations


Desulfurizations


Deoxygenations


Hydrodediazoniations


Synthesis of 1,4-cyclohexadienes


Reduction of aromatic compounds


Reduction of alkenes


Reduction of alkynes


Reduction of α,β-unsaturated compounds


Reduction of epoxides


Reduction of carboxyl compounds


Reduction of acid chlorides


Reduction of esters


Reduction of amides


Reduction of amides


Recent Literature


The preparation of alkenyl halides of any length from inexpensive starting reagents is reported. Standard organic transformations were used to prepare straight-chain α-olefin halides in excellent overall yields with no detectable olefin isomerization and full recovery of any unreacted starting material.
T. W. Baughman, J. C. Sworen, K. B. Wagener, Tetrahedron, 2004, 60, 10943-10948.


Addition of in situ generated Schwartz reagent to widely available isocyanates enables a chemoselective, high-yielding, and versatile synthesis of variously functionalized formamides. The reaction tolerates the presence of sensitive functionalities (esters, nitro groups, nitriles, alkenes).
V. Pace, K. de la Vega-Hernández, E. Urban, T. Langer, Org. Lett., 2016, 18, 2750-2753.