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Synthesis of amides by rearrangements or hydrolysis

Name Reactions


Beckmann Rearrangement


Ritter Reaction


Ritter Reaction


Recent Literature


A wide range of aldoximes has been converted into the corresponding amides in high yield and selectivity using the ruthenium-based catalyst Ru(PPh3)3(CO)H2/dppe/TsOH with catalyst loading as low as 0.04 mol%.
N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 3599-3601.


[Ir(Cp*)Cl2]2 catalyzes the rearrangement of oximes to furnish amides. An iridium-catalyzed transfer hydrogenation between alcohols and styrene and the subsequent formation of an oxime allows the conversion of alcohols into amides in a one-pot process.
N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 73-75.