Categories: C-N Bond Formation > Synthesis of azides >
Synthesis of alkyl azides
Recent Literature
A practical, rapid, and efficient microwave (MW) promoted nucleophilic
substitution of alkyl halides or tosylates with alkali azides, thiocyanates
or sulfinates in aqueous media tolerates various reactive functional groups.
Y. Ju, D. Kumar, R. S. Varma, J. Org. Chem., 2006,
71, 6697-6700.
A cobalt-catalyzed hydroazidation of α,α-disubstituted olefins with commercially
available azide sources provides tertiary azides in useful yields and tolerates
a variety of functional groups.
B. Gaspar, J. Waser, E. M. Carreira, Synthesis, 2007,
3839-3845.
A highly Marknovikov selectiv conversion of various olefins to azides
was achieved using a cobalt catalyst, 3 equiv of TsN3 as nitrogen
source and simple silanes (PhSiH3, TMDSO).
J. Waser, H. Nambu, E. M. Carreira, J. Am. Chem. Soc.,
2005,
127, 8294-8295.
A general, catalytic, and enantioselective synthesis of α-amino acids
E. J. Corey, J. O. Link, J. Am. Chem. Soc., 1992,
114, 1906-1908.
