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Synthesis of alkyl azides

Recent Literature

A practical, rapid, and efficient microwave (MW) promoted nucleophilic substitution of alkyl halides or tosylates with alkali adzides, thiocyanates or sulfinates in aqueous media tolerates various reactive functional groups.
Y. Ju, D. Kumar, R. S. Varma, J. Org. Chem., 2006, 71, 6697-6700.

A highly Marknovikov selectiv conversion of various olefins to azides was achieved using a cobalt catalyst, 3 equiv of TsN₃ as nitrogen source and simple silanes (PhSiH₃, TMDSO).
J. Waser, H. Nambu, E. M. Carreira, J. Am. Chem. Soc., 2005, 127, 8294-8295.

A general, catalytic, and enantioselective synthesis of α-amino acids
E. J. Corey, J. O. Link, J. Am. Chem. Soc., 1992, 114, 1906-1908.

 

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