Categories: C-N Bond Formation > Enamines

Synthesis of α-ketoenamines

Recent Literature

α,β-Dehydroamino acid derivatives were synthesized in good yields from α-bromoketones or α-bromoesters and hydroxamates via a sequential procedure involving displacement of bromide by hydroxamate anion, followed by a base-induced elimination-isomerization reaction.
Y. Sun, X. Wang, X. Zheng, K. Zhao, Synlett, 2008, 861-866.