Categories: C-N Bond Formation >
Synthesis of isocyanates
Recent Literature
Alkyl isocyanates are prepared in good to excellent yields by treatment of
alcohols, thiols and trimethylsilyl ethers with triphenylphosphine/2,3-dichloro-5,6-dicyanobenzoquinone/Bu4NOCN
in acetonitrile. This method is highly selective for conversion of primary
alcohols to alkyl isocyanates in the presence of secondary and tertiary alcohols,
thiols and trimethysilyl ethers.
B. Akhlaghinia, Synthesis, 2005,
1955-1958.
