Categories: C-N Bond Formation >
Synthesis of thioureas
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Recent Literature
A simple condensation between amines and carbon disulfide in aqueous medium
allows an efficient synthesis of symmetrical and unsymmetrical substituted
thiourea derivatives. This protocol works smoothly with aliphatic primary amines
to afford various di- and trisubstituted thiourea derivatives.
M. R. Maddani, K. R. Prabhu, J. Org. Chem., 2010,
75, 2327-2332.
Stable and readily available N,N'-di-Boc-substituted thiourea can be used
as a mild thioacylating agent when activated with trifluoroacetic acid anhydride.
Through thioacylation of nucleophiles, such as amines, alcohols, thiols, sodium
benzenethiolate, and sodium malonates, a series of thiocarbonyl compounds were
prepared with good chemical selectivity and functional group tolerance.
B.-L. Yin, Z.-G. Liu, J.-C. Zhang, Z.-R. Li, Synthesis, 2010,
991-999.
