Categories: C-N Bond Formation >
Synthesis of urea derivatives
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Name Reactions
Recent Literature
The arylation of N-H and O-H containing compounds at room temperature with
phenylboronic acids is promoted in the presence of cupric acetate and a tertiary
amine. Substrates include phenols, amines, anilines, amides, imides, ureas,
carbamates, and sulfonamides.
D. M. T. Chan, K. L. Monaco, R.-P. Wang, M. P. Winteres, Tetrahedron Lett.,
1998, 39, 2933-2936.
Imidazolidin-2-ones are prepared in two steps from readily available N-allylamines.
Addition of the amine starting materials to isocyanates affords N-allylureas,
which are converted to imidazolidin-2-ones with generation of two bonds and
up to two stereocenters in the presence of aryl bromides, a catalytic amount
of Pd2(dba)3/Xantphos and NaOtBu.
J. A. Fritz, J. S. Nakhla, J. P. Wolfe, Org. Lett.,
2006,
8, 2531-2534.
