Categories: C-O Bond Formation > Synthesis of alcohols (hydroxylation) >
Synthesis of β-hydroxy ketones, esters, nitriles and related compounds
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Recent Literature
The direct addition of water and a variety of alcohols to activated olefins
was observed in the presence of nucleophilic phosphine catalysts. Unlike
existing methods, the reactions proceed at room temperature and in the absence
of transition metals, or strong acids or bases.
I. C. Stewart, R. G. Bergman, F. D. Toste, J. Am. Chem. Soc., 2003,
125, 8696-8697.
A new palladium-catalyzed method allows the oxygenation of unactivated sp3
C-H bonds of a wide variety of alkane substrates containing readily
available oxime and/or pyridine directing groups with extremely high levels
of chemo-, regio-, and in some cases diastereoselectivity.
L. V. Desai, K. L . Hull, M. S. Sanford, J. Am. Chem. Soc.,
2004,
126, 9542-9543.
R. Shintani, K. Okamoto, T. Hayashi, Org. Lett.,
2005,
7, 4757-4759.
