Categories: C-O Bond Formation >
Synthesis of anhydrides
Name Reactions
Recent Literature
The reaction between carboxylic acids and dialkyl dicarbonates, in the presence
of a weak Lewis acid such as magnesium chloride and the corresponding alcohol as
the solvent, leads to esters in excellent yields. The mechanism involves a
double addition of the acid to the dicarbonate, affording a carboxylic anhydride
and CO2.
G. Bartoli, M. Bosco, A. Carlone, R. Dalpozzo, E. Marcantoni, P. Melchiorre, L.
Sambri, Synthesis, 2007,
3489-3496.
