Categories: C-O Bond Formation >
Synthesis of carbonates and related compounds
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Recent Literature
Mg(ClO4)2 is a stable and specific activator of
1,3-dicarbonyl compounds, that allows a smooth, direct synthesis of aryl and
alkyl ethyl carbonates.
G. Bartoli, M. Bosco, A. Carlone, M. Locatelli, E. Marcantoni, P. Melchiorre,
P. Palazzi, L. Sambri, Eur. J. Org. Chem., 2006,
4429-4434.
A very efficient Zinc acetate-catalyzed protection of alcohols as Boc
derivatives can be applied to primary, secondary and aromatic alcohols,
providing the first example of a generally applicable method.
G. Bartoli, M. Bosco, A. Carlone, R. Dalpozzo, M. Locatelli, P. Melchiorre, P.
Palazzi, L. Sambri, Synlett, 2006,
2104-2108.
The reaction of Grignard reagents with alkyl imidazolecarboxylates, which
were prepared from alcohols with carbonyl diimidazole, gave the
corresponding esters in good to excellent yields.
T. Werner, A. G. M. Barrett, J. Org. Chem., 2006,
71, 4302-4304.
An efficient method to activate hydroxyl groups of amino alcohols has been
developed, which avoids the use of toxic reagents and tolerates various
functional groups. This strategy has been applied to the synthesis of
functionalized p-methoxyphenyl-protected azetidines, pyrrolidines, and
piperidines.
R. M. de Figueiredo, R. Fröhlich, M. Christmann, J. Org. Chem., 2006,
71, 4147-4154.
A bimetallic titanium complex [(salen)TiO]2 catalyzes the asymmetric addition of ethyl cyanoformate to aldehydes leading to
cyanohydrin carbonates with high enantiomeric excesses.
Y. N. Belokon, A. J. Blacker, L. A. Clutterbuck, M. North, Org. Lett.,
2003, 5, 4505-4507.
