Categories: C-O Bond Formation >
Synthesis of 1,2-diols
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Recent Literature
Epoxides undergo rapid ring opening with a range of alcohols in the presence of
catalytic amount of carbon tetrabromide under mild and convenient conditions to
afford the corresponding β-alkoxy alcohols and 1,2-diols in high yields with
high regioselectivity.
J. S. Yadav, B. V. S. Reddy, K. Harikishan, Ch. Madan, A. V. Narsaiah,
Synthesis, 2005, 2897-2900.
Epoxides undergo rapid ring opening with a range of alcohols in the presence
of catalytic amount of carbon tetrabromide under mild and convenient
conditions to afford the corresponding β-alkoxy alcohols and 1,2-diols in
high yields with high regioselectivity.
J. S. Yadav, B. V. S. Reddy, K. Harikishan, Ch. Madan, A. V. Narsaiah,
Synthesis, 2005, 2897-2900.
Epoxides can be cleaved in a regio- and stereoselective manner under
neutral conditions with water, alcohols and acetic acid in the presence of
catalytic amounts of decatungstocerate(IV) ion, affording the corresponding
diols, β-alkoxy and β-acetoxy alcohols in high yields.
V. Mirkhani, S. Tangestaninejad, B. Yadollahi, L. Alipanah, Tetrahedron,
2003, 59, 8213-8218.
V. Mirkhani, S. Tangestaninejad, B. Yadollahi, L. Alipanah, Tetrahedron,
2003, 59, 8213-8218.
A very efficient and highly regioselective ring-opening reaction of epoxides
with benzoic acid and its derivatives in the presence of cat. amount of
tetrabutylammonium bromide (TBAB) in anhydrous acetonitrile gave selectively
protected diols.
A. Khalafi-Nezhad, M. N. Soltani Rad, A. Khoshnood, Synthesis,
2003, 2552-2558.
