Categories: C-O Bond Formation >
Synthesis of esters
An effective method for the construction of esters from acyl chloride and halohydrocarbon using Cs2CO3 as an oxygen source has a wide scope of substrates and can be scaled up. This esterification proceeds through a free radical reaction. CO2 can also be used as an oxygen source.
L. Ren, L. Wang, Y. Lv, G. Li, S. Gao, Org. Lett., 2015, 17, 5172-5175.
The chemoselective ring opening of N-tosyl aziridines with aldehydes catalyzed by an N-heterocyclic carbene gave carboxylates of 1,2-amino alcohols. A plausible mechanism for this reaction is discussed.
Y.-K. Liu, R. Li, L. Yue, B.-J. Li, Y.-C. Chen, Y. Wu, L.-S. Ding, Org. Lett., 2006, 8, 1521-1524.