Categories: C-O Bond Formation >
Synthesis of β-hydroxy ethers
Recent Literature
Epoxides undergo rapid ring opening with a range of alcohols in the presence of
catalytic amount of carbon tetrabromide under mild and convenient conditions to
afford the corresponding β-alkoxy alcohols and 1,2-diols in high yields with
high regioselectivity.
J. S. Yadav, B. V. S. Reddy, K. Harikishan, Ch. Madan, A. V. Narsaiah,
Synthesis, 2005, 2897-2900.
Epoxides can be cleaved in a regio- and stereoselective manner under
neutral conditions with water, alcohols and acetic acid in the presence of
catalytic amounts of decatungstocerate(IV) ion, affording the corresponding
diols, β-alkoxy and β-acetoxy alcohols in high yields.
V. Mirkhani, S. Tangestaninejad, B. Yadollahi, L. Alipanah, Tetrahedron,
2003, 59, 8213-8218.
