Categories: C-S Bond Formation > Synthesis of sulfones >
Synthesis of aryl sulfones and diaryl sulfones
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Recent Literature
A simple, mild and efficient method for the synthesis of unsymmetrical
diaryl sulfones using the palladium-catalyzed coupling of aryl boronic acids
and arylsulfonyl chlorides has been developed.
B. P. Bandgar, S. V. Bettigeri, J. Phopase, Org. Lett., 2004, 6, 2105-2108.
The palladium-catalyzed reaction of sulfinic acid salts with a wide variety
of aryl and vinyl halides or triflates, which is strongly influenced by the
presence of nBu4NCl, provides unsymmetrical diaryl
sulfones and aryl vinyl sulfones in good yields. The use of Xantphos, a
rigid bidentate ligand with a wide natural bite angle, was found to be
crucial for the success of the reaction.
S. Cacchi, G. Fabrizi, A. Goggiamani, L. M. Parisi, R. Bernini, J. Org.
Chem., 2004, 69, 5608-5614.
