Categories: C=N Bond Formation >
Synthesis of amidines
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Recent Literature
The addition of amines to nitriles catalyzed by ytterbium amides gives
monosubstituted N-arylamidinates in good to excellent yields at 100°C
under solvent-free conditions.
J. Wang, F. Xu, Q. Shen, Org. Lett., 2008,
10, 445-448.
A highly efficient, mild, copper-catalyzed multicomponent reaction
for the synthesis of N-sulfonylamidines has been developed. This reaction has an
extremely wide scope with regard to all three coupling components of alkyne,
sulfonyl azide, and amine. Two plausible mechanistic pathways are discussed.
I. Bae, H. Han, S. Chang, J. Am. Chem. Soc.,
2005, 127, 2038-2039.
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