Synthesis of amides

Name Reactions

Recent Literature

Sodium perborate in acetic acid is an effective reagent for the oxidation of aromatic aldehydes to carboxylic acids, iodoarenes to (diacetoxyiodo)arenes, azines to N-oxides, and various sulphur heterocycles to S,S-dioxides. Nitriles undergo smooth oxidative hydration to amides when aqueous methanol is employed as solvent.
A. McKillop, D. Kemp, Tetrahedron, 1989, 45, 3299-3306.

Ru(OH)_x / Al₂O₃ acts as a heterogeneous catalyst for the hydration of activated and unactivated nitriles in water. This reaction can be performed with high selectivity and conversion to give amides. Furthermore, catalyst/product separation is easy and Ru(OH)_x / Al₂O₃ is recyclable.
K. Yamaguchi, M. Matsushita, N. Mizuno, Angew. Chem. Int. Ed., 2004, 43, 1576-1580.

[Ir(Cp*)Cl₂]₂ catalyzes the rearrangement of oximes to furnish amides. An iridium-catalyzed transfer hydrogenation between alcohols and styrene and the subsequent formation of an oxime allows the conversion of alcohols into amides in a one-pot process.
N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 73-75.

N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 73-75.

Several amides were obtained in high yields by an efficient method from the corresponding imines which are readily prepared from aldehydes. This procedure involves the oxidation of aldimines with m-CPBA and BF₃·OEt₂. In this reaction, the product is strongly influenced by the electron releasing capacity of the aromatic substituent (Ar).
G. An, M. Kim, J. Y. Kim, H. Rhee, Tetrahedron Lett., 2003, 44, 2183-2186.