Categories: C=O Bond Formation > Synthesis of carboxylic acids >
Synthesis of carboxylic acids by oxidation of benzylic substrates
Recent Literature
The oxidation of substituted toluenes by molecular oxygen to the
corresponding substituted benzoic acids using Co(C18H35O2)2/NH4Br
or Co(OAc)2/NaBr/AcOH as catalysts in the presence of a radical
initiator in non-acidic solvents was investigated.
F. Yang, J. Sun, R. Zheng, W. Qiu, J. Tang, M. He, Tetrahedron, 2004,
60, 1225-1228.
A methyl group at an aromatic nucleus is oxidized directly to the
corresponding carboxylic acid in the presence of molecular oxygen and catalytic
hydrobromic acid under photoirradiation.
S.-I. Hirashima, A. Itoh, Synthesis, 2006, 1757-1759.
