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Categories: C=O Bond Formation > Synthesis of Ketones

Synthesis of α-keto carboxylic acids, esters and amides

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The reaction of aryl diazoacetates with H2O and diethyl azodicarboxylate (DEAD) catalyzed by dirhodium acetate gives aryl α-keto esters in high yields.
Z. Guo, H. Huang, Q. Fu, W. Hu, Synlett, 2006, 2486-2488.