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Synthesis of thioketones

Name Reactions


Lawesson's Reagent


Recent Literature


An expeditious, solvent-free, and high yield conversion of ketones, flavones, isoflavones, lactones, amides, and esters to the corresponding thio analogues is described utilizing Lawesson's reagent in a process that circumvents the use of dry solvents and excess of the reagent.
R. S. Varma, D. Kumar, Org. Lett., 1999, 1, 697-700.


A novel, simple and convenient thionation protocol for carbonyl compounds with the system PSCl3/H2O/Et3N allows a clean, rapid, and efficient synthesis of a variety of thiocarbonyl compounds such as thioamides, thiolactams, thioketones, thioxanthones and thioacridone under solventless condition with microwave irradiation.
U. Pathak, L. K. Pandey, R. Tank, J. Org. Chem., 2008, 73, 2890-2893.