Categories: N-H Bond Formation >
Cleavage of imides
Protecting Groups
Recent Literature
Phthalimides are converted to primary amines in an efficient, two-stage,
one-flask operation using NaBH4/2-propanol, then acetic acid.
Phthalimides of α-amino acids are smoothly deprotected with no measurable loss
of optical activity.
J. O. Osby, M. G. Martin, B. Ganem, Tetrahedron Lett., 1984,
25, 2093-2096.
