Organic Chemistry Portal
Reactions > Organic Synthesis Search

Categories: N-H Bond Formation >

Reduction of hydroxamates (Weinreb amides)

Recent Literature


Neutral organic super-electron donors can be used as reducing agents for the cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good yields.
S. P. Y. Cutulic, J. A. Murphy, H. Farwaha, S.-Z. Zhou, E. Chrystal, Synlett, 2008, 2132-2136.