Categories: N-H Bond Formation >
Reduction of azides
Recent Literature
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Poly(ethylene glycol) (PEG) (400) has been found to be a
superior solvent over ionic liquids by severalfold in promoting the
hydrogenation of various functional groups using
Adams' catalyst. Both the catalyst and PEG were
recycled efficiently over 10 runs without loss of activity, and without substrate cross
contamination.
S. Chandrasekhar, S. Y. Prakash, C. L. Rao, J. Org. Chem., 2006, 71, 2196-2199.

Organic azides are easily and chemoselectively reduced to the corresponding amines by reaction
with dichloroindium hydride under very mild conditions. γ-Azidonitriles
give pyrrolidin-2-imines in an outstanding
cyclization.
L. Benati, G. Bencivenni, R. Leardini, D. Nanni, M. Minozzi, P. Spagnolo, R.
Scialpi, G. Zanardi, Org. Lett.,
2006, 8, 2499-2502.

A novel enantioselective synthesis of α-amino acids has been developed,
which is broad in scope, simple in application, and advantageous for many α-amino acids
of interest in chemistry, biology, medicine.
E. J. Corey, J. O. Link, J. Am. Chem. Soc., 1992,
114, 1906-1908.
