Cleavage of acetals

Protecting Groups

Tetrahydropyranyl Ethers

Recent Literature

Acetals and ketals are readily deprotected under neutral conditions in the presence of acetone and indium(III) trifluoromethanesulfonate as catalyst at room temperature or mild microwave heating conditions to give the corresponding aldehydes and ketones in good to excellent yields.
B. T. Gregg, K. C. Golden, J. F. Quinn, J. Org. Chem., 2007, 72, 5890-5893.

Er(OTf)₃ is an efficient Lewis acid catalyst in a mild deprotection of benzylidene derivatives.
A. Procopio, R. Dalpozzo, A. De Nino, L. Maiuolo, M. Nardi, G. Romeo, Org. Biomol. Chem., 2005, 3, 4129-4133.

A new and efficient method for the cleavage of the PMP, THP and 1,3-dithiane protecting groups with Selectfluor™ has been developed.
J. Liu, C.-H. Wong, Tetrahedron Lett., 2002, 43, 4037-4039.

A simple and efficient method has been developed for chemoselective deprotection of phenolic methoxymethyl (MOM) ethers at room temperature using silica-supported sodium hydrogen sulfate as a heterogeneous catalyst.
C. Ramesh, N. Ravindranath, B. Das, J. Org. Chem., 2003, 68, 7101-7103.