Categories: Synthesis of N-Heterocycles, Synthesis of O-Heterocycles >

Synthesis of 1,2,4-oxadiazoles

Recent Literature

A one-pot reaction between nitriles, hydroxylamine and Meldrum’s acids under microwave irradiation and solvent-free conditions gives 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields.
M. Adib, M. Mahdavi, N. Mahmoodi, H. Pirelahi, H. R. Bijanzadeh, Synlett, 2006, 1765-1767.

A series of α-amino acid-derived 1,2,4-oxadiazoles have been synthesized via a convenient and inexpensive one-pot protocol in good yields and in relatively short reaction times.
A. L. Braga, D. S. Lüdtke, E. E. Alberto, L. Dornelles, W. A. Severo Filho, V. A. Corbellini, D. M. Rosa, R. S. Schwab, Synthesis, 2004, 1589-1594.

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