Synthesis of 2-oxazolones
General and efficient methods allow the synthesis of 2-oxazolones and α-aminoketones from β,β-dibromoenamides depending on the choice of R groups and the reaction conditions. On the basis of mechanistic studies, both reactions proceed via an intermolecular Suzuki-Miyaura C-C coupling and an intramolecular C-O coupling.
D. I. Chai, L. Hoffmeister, M. Lautens, Org. Lett., 2011, 13, 106-109.