Categories: Synthesis of N-Heterocycles >
Synthesis of 2-pyridones
Recent Literature
Formation of N-alkenyl alkynylamides by N-acylation of imines with
alkynoyl chlorides and the subsequent cationic Au(I)/PPh3-catalyzed
cycloisomerization allows a convergent and rapid assembly of substituted
2-pyridones.
H. Imase, K. Noguchi, M. Hirano, K. Tanaka, Org. Lett.,
2008,
10, 3563-3566.
CuI-catalyzed coupling reactions of tetrabutylammonium pyridin-2-olates with
aryl iodides allow an efficient synthesis of N-aryl pyridine-2-ones. This
coupling reaction is mild, high-yielding, remarkably chemoselective (N- vs.
O-arylation), and tolerates labile functional groups.
H. Zhang, B.-C. Chen, B. Wang, S. T. Chao, R. Zhao, N. Lim, B. Balasubramanian, Synthesis, 2008,
1523-1524.
