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Synthesis of tetrahydroquinoxalines

Recent Literature

The use of HBpin as a hydrogen source enables a metal-free environmentally benign, simple, and efficient transfer hydrogenation process of quinoxalines to provide the desired tetrahydroquinoxalines in good yields in the presence of Bu₄NBr as a noncorrosive and low-cost catalyst.
Q. Guo, J. Chen, G. Shen, G. Lu, X. Yang, Y. Tang, Y. Zhu, S. Wu, B. Fan, J. Org. Chem., 2022, 87, 540-546.

S_N2-type ring-opening of activated aziridines with 2-bromoanilines followed by a Pd-catalyzed intramolecular C-N bond formation enable a highly regio- and stereoselective route for the synthesis of racemic and nonracemic tetrahydroquinoxalines.
M. K. Ghorai, A. K. Sahoo, S. Kumar, Org. Lett., 2011, 13, 5972-5975.