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Synthesis of Chromanones

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The first enantioselective intramolecular catalytic Stetter reaction, which opens up a short and efficient pathway to enantiomerically enriched chroman-4-ones, is reported.
D. Enders, K. Breuer, J. Runsink, Helv. Chim. Acta, 1996, 79, 1899-1902.


A highly enantio- and diastereoselective intramolecular Stetter reaction has been developed. Aliphatic and aromatic aldehydes and a broad range of trisubstituted Michael acceptors have been found to afford the desired products in good overall yield with high enantio- and diastereoselectivity.
J. Read de Alaniz, T. Rovis, J. Am. Chem. Soc., 2005, 127, 6284-6289.


An N-Heterocyclic carbene efficiently catalyzed an intramolecular nucleophilic substitution reaction to yield benzopyrones and benzofuranones depending on the substitution pattern.
J. He, J. Zheng, J. Liu, X. She, X. Pan, Org. Lett., 2006, 8, 4637-4640.