Organic Chemistry Portal
Reactions > Organic Synthesis Search

Categories: Synthesis of N-Heterocycles >

Synthesis of indolizines

Recent Literature


An efficient and one-step synthesis of 3-aminoindolizines or benz[e]indolizines from the reactions of propargyl amines or amides with heteroaryl bromides is realized by a tandem reaction using Pd/Cu catalysts, which catalyze coupling and cycloisomerization reactions in the same vessel.
Y. Liu, Z. Song, B. Yan, Org. Lett., 2007, 9, 409-412.


An Au-catalyzed synthesis of fused pyrroloheterocycles from diverse propargyl-substituted heterocycles proceeds via alkyne-vinylidene isomerization with concomitant 1,2-shift of hydrogen, silyl, and stannyl groups. This method allows for mild and efficient synthesis of diverse C-2 substituted N-heterocycles.
I. V. Seregin, V. Gevorgyan, J. Am. Chem. Soc., 2006, 128, 12050-12051.