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Synthesis of indolizinones

Recent Literature

A copper-catalyzed cycloisomerization of 2-pyridyl-substituted propargylic acetates and its derivatives offers an efficient route to C-1 oxygenated indolizines with a wide range of substituents under mild reaction conditions. The presented method could be readily applied to the synthesis of indolizinones through a cyclization/1,2-migration of tertiary propargylic alcohols.
B. Yan, Y. Zhou, H. Zhang, J. Chen, Y. Liu, J. Org. Chem., 2007, 72, 7783-7786.