Categories: Synthesis of O-Heterocycles >
Synthesis of Isocoumarins
Recent Literature
Addition of a catalytic amount of Cy2NH·HX improves the rate and
yields for cyclization reactions of o-(alkynyl)benzoates in the presence
of a stoichiometric amount of copper(II)halide to give 4-haloisocoumarins. Under
the standard reaction conditions, various 4-haloisocoumarins are provided in
good yield.
Y. Liang, Y.-X. Xie, J.-H. Li, Synthesis, 2007,
400-406.
