Categories: Synthesis of O-Heterocycles >
Synthesis of Isocoumarins
Recent Literature
p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst
for the annulation of various functionalized diarylalkynes under microwave
irradiation. This metal-free process allowed the synthesis of various
3-aryl-substituted isocoumarins in good yields.
G. Le Bras, A. Hamze, S. Messaoudi, O. Provot, P.-B. Le Calvez, J.-D. Brion, M.
Alami, Synthesis, 2008,
1607-1611.
Addition of a catalytic amount of Cy2NH·HX improves the rate and
yields for cyclization reactions of o-(alkynyl)benzoates in the presence
of a stoichiometric amount of copper(II)halide to give 4-haloisocoumarins. Under
the standard reaction conditions, various 4-haloisocoumarins are provided in
good yield.
Y. Liang, Y.-X. Xie, J.-H. Li, Synthesis, 2007,
400-406.
