Categories: Synthesis of N-Heterocycles > Lactams >
Synthesis of α-lactams (aziridinones)
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A high-yielding general synthesis of α-lactams (aziridinones) is described.
An α-haloamide precursor is cyclized by sodium hydride in the presence of
15-crown-5 ether at room temperature, using dichloromethane as the solvent.
The by-products, hydrogen gas and sodium halide, are easily removed.
V. Cesare, T. M. Lyons, I. Lengyel, Synthesis, 2002, 1716-1720.