Categories: Synthesis of N-Heterocycles >
Synthesis of oxindoles
Recent Literature

A highly regioselective palladium-catalyzed cyclization converts
α-chloroacetanilides to oxindoles in good to excellent yields with high
functional group compatibility using 2-(di-tert-butylphosphino)biphenyl
as ligand and triethylamine as a stoichiometric base.
E. J. Hennessy, S. L. Buchwald, J. Am. Chem. Soc.,
2003, 125, 12084-12085.

A small library of α,β-unsaturated oxindoles was prepared by an efficient
microwave-assisted one-pot sequence comprising an aromatic substitution
followed by an ionic Horner-Wadsworth-Emmons olefination.
A. Teichert, K. Jantos, K. Harms, A. Studer, Org. Lett., 2004, 6, 3477-3480.
