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Synthesis of piperazines

Recent Literature

A highly diastereoselective intramolecular hydroamination is the key step in a modular synthesis of 2,6-disubstituted piperazines. The requisite hydroamination substrates were prepared in excellent yields by nucleophilic displacement of cyclic sulfamidates derived from amino acids. Various alkyl and aryl substituents at the 2-position were tolerated.
B. M. Cochran, F. E. Michael, Org. Lett., 2008, 10, 329-332.