Categories: Synthesis of N-Heterocycles >
Synthesis of pyrazolidines
Recent Literature
A catalyst composed of Pd(OAc)2 and S-Phos allows the conversion
of aryl chlorides as electrophiles in Pd-catalyzed alkene carboamination and
carboetherification, minimizes N-arylation, and prevents formation of
regiosisomieric mixtures. Various heterocycles, including pyrrolidines,
isoxazolidines, tetrahydrofurans, and pyrazolidines, are efficiently generated
with this method.
B. R. Rosen, J. E. Ney, J. P. Wolfe, J. Org. Chem., 2010,
75, 2756-2759.
The in situ generation of α-amino aldehydes followed by reaction
with
dimethyloxosulfonium methylide under Corey-Chaykovsky reaction conditions gives 4-hydroxypyrazolidine derivatives in high yields
with excellent enantio- and diastereoselectivities. This organocatalytic
sequential method enables an efficient synthesis of
anti-1,2-aminoalcohols.
B. S. Kumar, V. Venkataramasubramanian, A. Sudalai, Org. Lett., 2012,
14, 2468-2471.