Synthesis of S-Heterocycles

Synthesis of
Thiiranes	Thioacetals	Oxathioacetals	Sultams
Thiophenes Benzothiphenes	Thiazoles Benzothiazoles	1,3,4- Thiadiazoles

 

Protecting Groups

1,3-Dithianes, 1,3-Dithiolanes

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Recent Literature

A mild reaction of α,α-difluoroalkyl amines with β-amino alcohols, β-amino thiols, and β-diamines affords the corresponding oxazoline, thiazoline, and imidazoline derivatives, respectively. The conditions are applicable for the synthesis of optically active heterocyclic compounds.
T. Fukuhara, C. Hasegawa, S. Hara, Synthesis, 2007, 1528-1534.

A highly efficient and stereoselective gold-catalyzed cycloisomerization of α-thioallenes to 2,5-dihydrothiophenes has been discovered.
N. Morita, N. Krause, Angew. Chem. Int. Ed., 2006, 45, 1897-1899.

A mild ICl-induced cyclization of heteroatom-substituted alkynones provides a simple, highly efficient approach to various 3-iodochromones, iodothiochromenones, iodoquinolinones and analogues in good to excellent yields. Subsequent palladium-catalyzed transformations afford a rapid increase in molecular complexity.
C. Zhou, A. V. Dubrovsky, R. C. Larock, J. Org. Chem., 2006, 71, 1728-1731.

A three-component condensation gave 2-amino-4H-1,3-oxazines or 2-amino-4H-1,3-thiazines from alkynes, urea or thiourea, and aldehydes.
S. Huang, Y. Pan, Y. Zhu, A. Wu, Org. Lett., 2005, 7, 3797-3799.

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