Synthesis of sultams and related compounds
Highly strained β-sultams, sulfonyl analogues of β-lactams, were prepared enantio- and diastereoselectively by tertiary amine catalyzed [2 + 2] cycloaddition reactions. β-Sultams are practical precursors of highly enantioenriched β-aminosulfonyl derivatives of biological interest.
M. Zajac, R. Peters, Org. Lett., 2007, 9, 2007-2010.
Ring-closing metathesis (RCM) enables the synthesis of various of N-substituted five-membered sultams in good to excellent yields by reaction. As many sultams precipitated from the reaction mixture, an easy separation by filtration was possible.
S. Mondal, S. Debnath, Synthesis, 2014, 46, 368-374.
A one-pot method for the Sonogashira coupling and cyclization of 2-bromobenzenesulfonamides and terminal alkynes allows access to various substituted benzosultams regioselectively in excellent yields.
S. Debnath, S. Mondal, J. Org. Chem., 2015, 80, 3940-3948.