Totally Synthetic by Paul H. Docherty, 29 March 2006

Total Synthesis of Bistramide A

Crimmins

M. T. Crimmins, A. C. DeBaillie, J. Am. Chem. Soc. 2006, 128, 4936-4937.

DOI: 10.1021/ja057686l

All in the name, this one. Bistramide A is obviously a bisamide, so even the undergrads would get the major disconnections in this one! They install the spiroketal very nicely though, alkylating and hydrogenating to give the desired product in 83% over two steps.